Primary sclerosing cholangitis (PSC) is a biliary disease characterized by liver inflammation
and death of cholangiocytes which, in turn, drive to fibrosis, cirrhosis and functional alterations
of the liver. PSC is also associated with an increased risk of developing cholangiocarcinoma. To date,
the etiopathogenesis of PSC is still not completely understood, although a genetic predisposition in
association to environmental factors contribute to immune-mediated liver damage. The lack of such
knowledge is responsible for the failure of most available therapies. At this time, many studies are
evaluating potential approaches that could have a positive impact on the progression of the disease.
This review aims to provide a summary of present and past therapeutic approaches for PSC.
Keywords: Primary sclerosing cholangitis, cholestasis, pathogenesis, inflammatory bowel disease, diagnosis, treatment.
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