Title:Tumor Thermal Ablation Enhancement by Micromaterials
VOLUME: 14 ISSUE: 3
Author(s):Fan Zhao, Hongying Su*, Xiangjun Han, Han Bao and Ji Qi
Affiliation:Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning, Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning, Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning, Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning, Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning
Keywords:Microbubble, microcapsule, microsphere, thermal ablation, tumor.
Abstract:Thermal ablation is a minimally invasive therapeutic technique that has shown remarkable
potential in treating unresectable tumors. However, clinical applications have stalled, due to safety ambiguities,
slow heat induction, lengthy ablation times, and post-therapeutic monitoring issues. To further
improve treatment efficacy, an assortment of micromaterials (e.g., nanoparticulates of gold, silica, or
iron oxide and single-walled carbon nanotubes) are under study as thermal ablative adjuncts. In recent
years, the micromaterial domain has become especially interesting. In vivo and in vitro animal studies
have validated the use of microspheres as embolic agents in liver tumors, in advance of radiofrequency
ablation. Microcapsules and microbubbles serving as ultrasound contrast and ablation sensibilizers are
strong prospects for clinical applications. This review was conducted to explore benefits of the three
aforementioned microscale technologies, in conjunction with tumor thermal ablation.
