Abstract
Thermal ablation is a minimally invasive therapeutic technique that has shown remarkable potential in treating unresectable tumors. However, clinical applications have stalled, due to safety ambiguities, slow heat induction, lengthy ablation times, and post-therapeutic monitoring issues. To further improve treatment efficacy, an assortment of micromaterials (e.g., nanoparticulates of gold, silica, or iron oxide and single-walled carbon nanotubes) are under study as thermal ablative adjuncts. In recent years, the micromaterial domain has become especially interesting. In vivo and in vitro animal studies have validated the use of microspheres as embolic agents in liver tumors, in advance of radiofrequency ablation. Microcapsules and microbubbles serving as ultrasound contrast and ablation sensibilizers are strong prospects for clinical applications. This review was conducted to explore benefits of the three aforementioned microscale technologies, in conjunction with tumor thermal ablation.
Keywords: Microbubble, microcapsule, microsphere, thermal ablation, tumor.
Current Drug Delivery
Title:Tumor Thermal Ablation Enhancement by Micromaterials
Volume: 14 Issue: 3
Author(s): Fan Zhao, Hongying Su*, Xiangjun Han, Han Bao and Ji Qi
Affiliation:
- Department of Radiology, the First Hospital of China Medical University, 155 Nanjing North Street, Shenyang 110001, Liaoning,China
Keywords: Microbubble, microcapsule, microsphere, thermal ablation, tumor.
Abstract: Thermal ablation is a minimally invasive therapeutic technique that has shown remarkable potential in treating unresectable tumors. However, clinical applications have stalled, due to safety ambiguities, slow heat induction, lengthy ablation times, and post-therapeutic monitoring issues. To further improve treatment efficacy, an assortment of micromaterials (e.g., nanoparticulates of gold, silica, or iron oxide and single-walled carbon nanotubes) are under study as thermal ablative adjuncts. In recent years, the micromaterial domain has become especially interesting. In vivo and in vitro animal studies have validated the use of microspheres as embolic agents in liver tumors, in advance of radiofrequency ablation. Microcapsules and microbubbles serving as ultrasound contrast and ablation sensibilizers are strong prospects for clinical applications. This review was conducted to explore benefits of the three aforementioned microscale technologies, in conjunction with tumor thermal ablation.
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Cite this article as:
Zhao Fan , Su Hongying *, Han Xiangjun , Bao Han and Qi Ji , Tumor Thermal Ablation Enhancement by Micromaterials, Current Drug Delivery 2017; 14 (3) . https://dx.doi.org/10.2174/1567201813666160108114208
DOI https://dx.doi.org/10.2174/1567201813666160108114208 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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