Background: Cancer hyperthermia is attracting much attention in basic science and clinics.
Among the hyperthermia techniques, microwave (MW) heating is most commonly used for cancer
treatment. It offers highly competitive advantages: faster heat generation from microwave radiation, less
susceptibility to heat up local tissues, maneuverability, and depth of penetration in tissues and capability
of killing tumor cells. Although the encouraging clinical results are being collected, MW hyperthermia
has its own challenges, such as inaccurate targeting and low selectivity, which lead to damage to the
surrounding vital organs and tissues. To address these issues, this review aims to introduce micronanomaterials
as promising agents for receiving the electromagnetic wave, which should be beneficial
for improving the efficacy of MW hyperthermia.
Methods: We have searched many peer-reviewed papers in medical and chemical material databases
about micro-nanomaterials for tumor microwave hyperthermia. Distinguishing features and important
progresses are introduced in this review.
Results: One hundred and forty papers were chosen and included in this review. Four parts were described,
including hyperthermia techniques and the application of micro-nanomaterials, microwave
thermal therapy and treatment principle, microwave absorbing micro-nanomaterials, the preparation and
application of micro-nanomaterials in microwave thermal therapy.
Conclusion: We review the most recent literatures on micro-nanomaterials-based MW heating strategies
for cancer treatment, with the aim to give the reader an overview of the state-of-the-art of MW hyperthermia
therapy. The future of MW responsive materials will also be discussed, including combination
of imaging probes and targeting moieties.