Parkinson’s disease (PD) is a movement disorder and is associated with some of the
intellectual disabilities like cognitive dysfunctions. PD associated cognitive dysfunctions have been
proved well in both preclinical and clinical set ups. Like other neurodegenerative diseases, insults to
mitochondria have a significant role in the pathobiology of PD associated dementia (PDD).
Neurotoxins like MPTP, mutations of the mitochondrial genes, oxidative stress, imbalanced redox
mechanisms and dysregulated mitochondrial dynamics have been implicated in mitochondrial
dysfunctions and have paramount importance in the pathobiology of PDD. However, the extent of contribution of
mitochondrial dysfunctions towards cognitive deficits in PD has not been characterized completely. In this review we
highlight on the contribution of mitochondrial dysfunction to PDD. We also highlight different behavioural tests used in
nonhuman primate and rodent models for assessing cognitive deficits and some common techniques for evaluation of
mitochondrial dysfunction in PDD.
Keywords: Cognitive impairments, mitochondrial biogenesis, mitochondrial dysfunction, mitochondrial transcription factor A,
neurodegeneration, Parkinson’s Disease.
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