Comprehensive Practical Hepatology

Acute and chronic liver disease is a global endemic healthcare concern. More than 500 million people around the world are infected with the hepatitis B or C virus. Approximately 500,000 patients die ...
[view complete introduction]

US $

*(Excluding Mailing and Handling)

Liver Function Abnormalities in Systemic Disease

Pp. 147-155 (9)

Yukihiro Shimizu


There are many possible causes of abnormal liver function test results, including viral hepatitis, alcohol consumption, nonalcoholic fatty liver disease, autoimmune liver diseases, hereditary diseases, hepatobiliary malignancies or infection, gallstones, and drug-induced liver injury. Moreover, the liver may be involved in systemic diseases that mainly affect other organs. Therefore, in patients without etiology of liver injury based on screening serology and diagnostic imaging analysis, abnormal liver function test results may be due to systemic disease. In most of these patients, systemic disease should be the primary focus of treatment. However, some patients with systemic disease and severe liver injury or fulminant hepatic failure require intensive treatment of the liver.


Adrenal gland disease, amyloidosis, connective tissue disease, diabetes mellitus, granuloma, heart failure, metastatic liver tumor, postoperative liver injury, sepsis, shock liver, systemic infection, thyroid disease, total parental nutrition.


Gastroenterology Center, Nanto Municipal Hospital, Toyama, Japan.