Nanosuspension: Principles, Perspectives and Practices

Author(s): Sachin Kumar Singh, Yogyata Vaidya, Monica Gulati, Sibasis Bhattacharya, Varun Garg, Narendra Kumar Pandey

Journal Name: Current Drug Delivery

Volume 13 , Issue 8 , 2016


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Abstract:

In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions offer versatile features and unique advantages over other approaches that have been utilized for this purpose. The unique inherent properties of nanosuspensions have been explored for a wide variety of applications. Commercial production of stable nanosuspensions has been made possible by the use of techniques such as media milling and high pressure homogenization. This article reviews various techniques being employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to overcome their stability and commercialization related aspects are also highlighted.

Keywords: Bottom up technology, Characterization, High pressure homogenization, Media milling, Nanosuspension, Stability.

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Article Details

VOLUME: 13
ISSUE: 8
Year: 2016
Published on: 07 November, 2016
Page: [1222 - 1246]
Pages: 25
DOI: 10.2174/1567201813666160101120452
Price: $65

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