In the last three decades, nano-sizing of hydrophobic drugs has emerged as one of the most
commonly used strategies to overcome their solubility and bioavailability related issues. Nanosuspensions
offer versatile features and unique advantages over other approaches that have been utilized for this purpose.
The unique inherent properties of nanosuspensions have been explored for a wide variety of applications.
Commercial production of stable nanosuspensions has been made possible by the use of techniques
such as media milling and high pressure homogenization. This article reviews various techniques being
employed for production, characterization, merits and limitations of nanosuspensions and mechanisms that
play a role in the physicochemical stability of nanosuspensions. The common strategies applied so far to
overcome their stability and commercialization related aspects are also highlighted.
Keywords: Bottom up technology, Characterization, High pressure homogenization, Media milling, Nanosuspension, Stability.
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