Abstract
Medicinal combinations of Isaria japonica (Paecilomyces tenuipes, Paecilomyces japonica, and Isaria tenuipes) and the silkworm Bombyx mori are commercially available in Japan, China, and Korea. Isaria japonica exhibits host specificity for lepidopteran insects and can be cultured in the insect’s body. Recently, a hot-water extract of an I. japonica product (“IJE”) was shown to prevent brain function decline in aging mice. Therefore, evaluating the safety profile of IJE is worthwhile. Acute toxicity experiments were performed on adult female ICR mice (8-10 weeks old; 25-35 g). Sub-chronic toxicity experiments on adult female Wistar rats (8-10 weeks old; 130-150 g) assessed general behavior, mortality, body weight, food + water consumption, hematology, blood chemistry, relative organ weights and histopathology. IJE caused neither significant visible signs of toxicity nor mortality in ICR mice. In the sub-chronic toxicity analysis, administration of IJE to Wistar rats at doses of 25 and 500 mg/kg for 28 consecutive days did not cause mortality. No significant differences were found in food or water consumption, hematological parameters, or relative organ weights between the treated and control groups. IJE appears to be safe when administered orally.
Keywords: Acute toxicity, Animals, Biochemical parameters, Hot-water extract, Isaria japonica, subchronic toxicity.
Current Traditional Medicine
Title:Acute and Sub-chronic Toxicity Analyses of Hot-Water Extract of Isaria japonica from Silkworm (Bombyx mori) Pupae
Volume: 1 Issue: 3
Author(s): Piyamas Sillapakong, Masanobu Goryo, Jun Sasaki, Shinichi Oda, Takashi Hiraga, Shorta Uchiyama, Eiji Nishimura, Tetsuro Shinada, Chigumi Ohtsuka, Yasuo Terayama and Koichi Suzuki
Affiliation:
Keywords: Acute toxicity, Animals, Biochemical parameters, Hot-water extract, Isaria japonica, subchronic toxicity.
Abstract: Medicinal combinations of Isaria japonica (Paecilomyces tenuipes, Paecilomyces japonica, and Isaria tenuipes) and the silkworm Bombyx mori are commercially available in Japan, China, and Korea. Isaria japonica exhibits host specificity for lepidopteran insects and can be cultured in the insect’s body. Recently, a hot-water extract of an I. japonica product (“IJE”) was shown to prevent brain function decline in aging mice. Therefore, evaluating the safety profile of IJE is worthwhile. Acute toxicity experiments were performed on adult female ICR mice (8-10 weeks old; 25-35 g). Sub-chronic toxicity experiments on adult female Wistar rats (8-10 weeks old; 130-150 g) assessed general behavior, mortality, body weight, food + water consumption, hematology, blood chemistry, relative organ weights and histopathology. IJE caused neither significant visible signs of toxicity nor mortality in ICR mice. In the sub-chronic toxicity analysis, administration of IJE to Wistar rats at doses of 25 and 500 mg/kg for 28 consecutive days did not cause mortality. No significant differences were found in food or water consumption, hematological parameters, or relative organ weights between the treated and control groups. IJE appears to be safe when administered orally.
Export Options
About this article
Cite this article as:
Sillapakong Piyamas, Goryo Masanobu, Sasaki Jun, Oda Shinichi, Hiraga Takashi, Uchiyama Shorta, Nishimura Eiji, Shinada Tetsuro, Ohtsuka Chigumi, Terayama Yasuo and Suzuki Koichi, Acute and Sub-chronic Toxicity Analyses of Hot-Water Extract of Isaria japonica from Silkworm (Bombyx mori) Pupae, Current Traditional Medicine 2015; 1 (3) . https://dx.doi.org/10.2174/221508380103151231145946
DOI https://dx.doi.org/10.2174/221508380103151231145946 |
Print ISSN 2215-0838 |
Publisher Name Bentham Science Publisher |
Online ISSN 2215-0846 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Determination of Three Tyrosine Kinase Inhibitors and One Active Metabolite by an Identical and Validated Ultra-performance Liquid Chromatography-DAD Method in Human Plasma
Current Pharmaceutical Analysis Advances in Anticancer Antibody-Drug Conjugates and Immunotoxins
Recent Patents on Anti-Cancer Drug Discovery The Role of microRNAs in the Pathogenesis and Treatment of Hematopoietic Malignancies
Current Pharmaceutical Design Status of Flavonols as P-Glycoprotein Inhibitors in Cancer Chemotherapy
Current Cancer Therapy Reviews Analysis of Fish IL-1β and Derived Peptide Sequences Indicates Conserved Structures with Species-Specific IL-1 Receptor Binding: Implications for Pharmacological Design
Current Pharmaceutical Design Meet Our Editorial Board Member
Current Cancer Drug Targets An Integrative Informatics Approach to Explain the Mechanism of Action of N1-(Anthraquinon-2-yl) Amidrazones as BCR/ABL Inhibitors
Current Computer-Aided Drug Design Oncogenic MicroRNAs in the Genesis of Leukemia and Lymphoma
Current Pharmaceutical Design Mevalonate Kinase Deficiency: Disclosing the Role of Mevalonate Pathway Modulation in Inflammation
Current Pharmaceutical Design Herpesvirus Saimiri-Based Gene Delivery Vectors
Current Gene Therapy Immunogenic Issues Concerning Recombinant Adeno-Associated Virus Vectors for Gene Therapy
Current Gene Therapy Obesity Modulation - The Role in Carcinogenesis
Anti-Cancer Agents in Medicinal Chemistry Understanding XPO1 Target Networks Using Systems Biology and Mathematical Modeling
Current Pharmaceutical Design Emerging Roles for Modulation of microRNA Signatures in Cancer Chemoprevention
Current Cancer Drug Targets Discovery and Design of Peptides as MMP9 Inhibitors through Structure-Based Molecular Docking for Targeted Mantle Cell Lymphoma Therapy
Anti-Cancer Agents in Medicinal Chemistry The Application of Single Nucleotide Polymorphism Microarrays in Cancer Research
Current Genomics Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease Genes
Current Gene Therapy Busulphan in Blood and Marrow Transplantation: Dose, Route, Frequency and Role of Therapeutic Drug Monitoring
Current Clinical Pharmacology Main Nutritional and Environmental Risk Factors in Children with Leukemia from a Public Hospital of the State of Guanajuato, Mexico
Current Cancer Therapy Reviews Elevated Levels of Soluble Fibrin in Patients with Thrombosis or a Pre- Thrombotic State
Vascular Disease Prevention (Discontinued)