Use of Diverse Chemometric and Validation Methods to Accurately Predict Human Urotensin-II Receptor Antagonist Activity

Author(s): Anubhuti Pandey, Sarvesh Paliwal, Rakesh Yadav, Shailendra Paliwal

Journal Name: Current Computer-Aided Drug Design

Volume 11 , Issue 4 , 2015

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Despite being identified as the most potent receptor related to vasoconstriction, human urotensin-II receptor (hUT) has not been fully explored as a target for the treatment of cardiovascular diseases. In view of this and with an aim to identify precise structural requirements for binding of hUT antagonists, we endeavoured to develop, for the first time, multivariate QSAR models using chemometric methods like partial least squares (PLS) and feed-forward neural network (FFNN). A set of 48 pyrrolidine derivatives having hUT binding affinity was used for multivariate model development. The accuracy and predictability of the developed models was evaluated using crossvalidation. The PLS model showed good correlation between selected descriptors and Ki values (r2 =0.745 and r2 (CV) =0.773). However, the predictive performance of FFNN was better than the PLS technique with r2 =0.810. The study clearly suggests the role of lipophilic and steric descriptors in the ligand-hUT interactions. The QSAR models generated can be successfully extended to predict the binding affinities and for the effective design of novel hUT antagonists.

Keywords: QSAR, urotensin-II, PLS, FFNN, descriptors, TSAR.

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Article Details

Year: 2015
Published on: 06 January, 2016
Page: [361 - 373]
Pages: 13
DOI: 10.2174/1874609809666151223093650
Price: $65

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