A catalyst-free condensation reaction of α,β-unsaturated ketones and sodium sulfide in
CH3CN-H2O mixture (1:1) was established to prepare a variety of polysubstituted tetrahydrothiopyrans
in good to excellent yields. The obtained tetrahydrothiopyrans were oxidized with
MCPBA to the corresponding sulfoxides in good yields. The present research is the first report on
synthesis of polysubstituted tetrahydrothiopyran sulfoxides
Keywords: α, β-unsaturated ketones, sodium sulfide, tetrahydrothiopyran, sulfoxides, synthesis.
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