Ethyl octyl phosphite (EOP), a dialkyl phosphite with mixed alkyl groups was
prepared, and utilized in the Kabachnik–Fields reaction. The condensation of EOP, paraformaldehyde
and primary or secondary amines used in equimolar quantities afforded new
α-aminophosphonates under microwave conditions. Methylation of the -α(alkylamino)phosphonates
was also investigated. The double phospha-Mannich reaction of primary amines and
two equivalents of EOP and paraformaldehyde furnished new bis(phosphonomethyl)amines.
Keywords: Ethyl octyl phosphite, Kabachnik–Fields reaction, Ethyl octyl α-aminomethyl-phosphonates, N, N-Bis(ethyloctylphosphonoylmethyl)
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