Background: Heterocyclic molecules have been synthesized by a green & facile strategy. These molecules
contain a 8-membered azocine ring. The structures have been determined by spectral analysis and single
crystal X-ray analysis. These compounds have anticancer activity.
Method: A mixture of ninhydrin and acetone/ethylmethylketone in acetic acid in molar ratio 1:1 were heated on
water bath for 15 minutes. The reaction mixtures were dried on rotary evaporator and crystallized with chloroform-
n-hexane (1:1 v/v) to give the colorless crystals of 1 And 2 respectively. Compounds 3 and 4 were synthesized
by adding o-phenylenediamine to the completed reaction mixtures of 1 and 2 and each was further heated
on water bath for 5 minutes. The dried reaction mixtures were chromatographed over a silica gel column and
crystalized as 3 and 4.
Results: This strategy resulted novel class of anticancer benzazocines (3 & 4).
Conclusion: This method features mild reaction conditions and simple operation. The synthesis completes in two
steps; from ninhydrin to 1 & 2 and from 1 & 2 to 3 & 4. The same basic skeleton of 3 & 4 and the same synthesis
procedure clearly shows the general applicability of this reaction that is also proved enough by single crystal Xray
analysis and the strategy can be applicable for a wide range of other substrates. The obtained compounds are
potential anticancer agents.