Embryonic implantation is the result of a highly coordinated immunological shift resulting
in a very localized, uterine specific, immune suppression of activated maternal response to fetal
alloantigens. Without this coordinated immunological shift the result would be fetal demise and
termination of genetic propagation. Hence, maternal immunological acceptance of the fetal allograft
is imperative for the survival of any species that participates in allogeneic mating. While these events
have occurred since the beginning of our species, the mechanisms and key factors that regulate this
immunological shift are still not well understood and continue to astonish immunologists and reproductive physiologists.
While we have not yet discovered all pathways utilized by our immune system to promote fetal tolerance, we are very
aware of the development of obstetrical complications that arise from improper maternal immune tolerance. This review
highlights key investigations that have focused on the discovery and role of regulatory T cells (Tregs) in the
pathophysiology of preeclampsia and how these cells impact the immune dynamics at the maternal fetal interface.
Keywords: Embryo, immune, implantation, maternal, preeclampsia, tregs.
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