Title:Who Should Receive Low-Dose Aspirin for Pre-eclampsia Prevention? Sorting through the Meta-Analyses
VOLUME: 11 ISSUE: 2
Author(s):David N. Hackney and Melissa I. March
Affiliation:Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Ave, MacDonald 7, Cleveland, OH 44106-5034, USA.
Keywords:Low dose aspirin, meta-analysis, pre-eclampsia.
Abstract:Low dose aspirin has been shown to reduce the risk for preeclampsia in certain
populations. The aim of this review was to provide an overview of the findings of the larger
randomized trials, meta-analyses and individual patient-data meta-analysis studying this topic. It is
difficult to draw exact conclusions for patient care given heterogeneity in inclusion criteria and
subgroups of both the individual trials and meta-analyses. The authors’ practice is to recommend low
dose aspirin to women, starting between 12 and 20 weeks gestational age, who have previously had
severe and/or preterm preeclampsia in a prior pregnancy. Individual institutions are recommended to establish guidelines
in order to standardize patient care, even in the context of uncertainty.
