Besides regulating the humoral immunity, the B cell activating factor
(BAFF) has also a crucial role in promoting pathogenic Th17 cell responses: the activity
of the cytokine is manifested in autoimmune disorders but also in the inflammatory
disease caused by the bacterium Helicobacter pylori. Thus, current evidence suggests
that BAFF antagonism may be efficacious in Th17 cell-driven diseases.
Keywords: Autoimmune disorders, BAFF, Helicobacter pylori, Sjogren’s syndrome, Th17 response, TNF.
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