For a variety of diseases, effective therapy is severely limited or rendered impossible due to an inability
to deliver medications to the intended sites of action. Multiple barriers exist through the body, which have evolved
over time to limit the migration of foreign compounds from entering the tissues. Turning toward biology as inspiration,
it has been the general goal of drug delivery to create carrier strategies that mimic, in part, features of bacteria/
viruses that allow them overcome these barriers. By packaging drugs into nano and micron scale vehicles, it
should be possible to completely change the biodistribution and residence times of pharmaceutically active compounds.
Recently, due to advances in formulation technologies, it has become possible to control not just the material
selection, surface chemistry, and/or size, but also the overall geometry and plasticity of the drug carriers. These
approaches aid in the formulation of nonspherical particles such as, discs, rods, and even unique structures such as
cubes and nanodiamonds. The adjustment of size and shape can be used for the aid or prevention in cellular uptake and also to overcome
the vascular and mucosal barrier. In this review, we present a summary of some approaches used to control carrier shape and the impact
these geometries have upon drug transport across biological barriers.