Title:Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities
VOLUME: 22 ISSUE: 11
Author(s):Babak Mostaghaci, Brigitta Loretz and Claus-Michael Lehr
Affiliation:Department of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI); Saarland University, Campus E8.1, 66123 Saarbrucken, Germany., Department of Drug Delivery (DDEL), Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI); Saarland University, Campus E8.1, 66123 Saarbrucken, Germany.
Keywords:Calcium phosphate, hydroxyapatite, bioceramics, gene delivery, transfection, biocompatibility.
Abstract:Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent
biocompatibility and simple application have motivated the researchers to always consider this system in
their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of
calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system.
In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses
in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to
improve the properties of this system are reviewed.
