Kinases are known to regulate the majority of human cellular processes such as communication, division,
metabolism, survival and apoptosis therefore they can be promising targets in cancer diseases, viral infection
and in other disorders. Small molecules acting as selective human protein kinase inhibitors are very attractive
pharmacological targets. This review presents a number of examples of biologically active natural and synthetic
benzo[b]furans and their derivatives, such as benzo[b]furan-2- and 3-ones, benzo[b]furan-2- and 3-carboxylic acids,
as well as benzo[c]furans as potential inhibitors of various human protein kinases. The pathways of function
and implication of the inhibitors in cancer and other diseases are discussed.