Introduction: Worldwide, iron deficiency anemia is the most common nutritional disorder.
Treatment with oral iron supplementation may not be well tolerated due to gastrointestinal side effects.
Therapy with Intravenous (IV) iron supplementation is more effective and better tolerated, especially
in patients with underlying Inflammatory Bowel Disease (IBD) or malignancy. However,
Hypersensitivity Reactions (HSR) and anaphylaxis to IV iron have been described.
Methods: We evaluated the literature and developed an eleven step desensitization protocol for ferric
carboxymaltose to be administered in high risk patients.
Results: We present the first case series demonstrating the safety of ferric carboxymaltose desensitization in patients with
a history of anaphylaxis to IV iron and iron deficiency anemia.
Conclusion: While there are many IV iron formulations available, ferric carboxymaltose can replenish iron stores with
fewer doses. Ferric carboxymaltose is contraindicated in patients with prior hypersensitivity reactions to iron
formulations. This novel eleven step desensitization protocol was well tolerated without any adverse reactions and
allowed the patients to receive iron supplementation when limited therapeutic options existed.