Title:Synthesis and Applications of Glyconanoparticles
VOLUME: 20 ISSUE: 14
Author(s):Baoyong Liu, Xiaowei Lu, Hong Ruan, Jiwei Cui and Hongguang Li
Affiliation:Carbohydrates Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 8, Room 1A21 Bethesda, MD, 20896 USA., Laboratory of Clean Energy Chemistry and Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Keywords:Glyconanoparticles, methodologies, carbohydrate-lectin interactions, biomedicine.
Abstract:Glyconanoparticles are the subject of numerous literatures and are emerging for applications in biomedicine,
glycoscience, and material science due to their unique properties. They are hybrid materials each of
which contains a nanoparticle core surrounded by a carbohydrate shell. The core can be metallic, magnetic, and/or
photoluminescent, while the shell may be composed of mono-, di-, oligo- and/or poly-saccharides. Sugars are attached to the surface of
the nanoparticles through covalent or non-covalent interaction. Here, we give a brief summary of the synthetic methodologies adopted in
the preparation of different types of glyconanoparticles, which can be utilized in various applications including catalysis, drug delivery,
vaccine, imaging and study of carbohydrate-lectin interactions.
