Diabetes and Pancreas: Why So Difficult? Potential Mechanisms of Elevated Serum Pancreatic Enzymes

Author(s): Elena Matteucci, Ottavio Giampietro

Journal Name: Current Medicinal Chemistry

Volume 23 , Issue 3 , 2016

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Diabetes mellitus has been associated with a higher risk of exocrine pancreas disorders despite inconsistencies among studies, presumably due to the presence of several (often unmeasured) confounding factors. As a direct consequence of this uncertainty, the relationship between anti-diabetic therapies and pancreatic adverse reactions is difficult to evaluate and remains far from being clarified. Indeed, the on going debate on the safety of incretin-based therapies does not lie in any definite conclusion.

Serum level of amylases and lipase reflects the balance between production from different tissues and clearance, but it may be also influenced by numerous molecular, cellular, and systems mechanisms. The present review tries to provide an overview of potential biochemical pathways that may underlie pancreatic hyperenzymemia in health and diabetes mellitus.

Keywords: Diabetes mellitus, amylases, lipase, pancreatitis, adverse drug reaction.

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Article Details

Year: 2016
Published on: 22 January, 2016
Page: [290 - 302]
Pages: 13
DOI: 10.2174/0929867323666151207111201
Price: $65

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