Development of Scaffolds for Vascular Tissue Engineering: Biomaterial Mediated Neovascularization

Author(s): Florin Iordache, Alexandru Mihai Grumezescu, Horia Maniu, Carmen Curutiu

Journal Name: Current Stem Cell Research & Therapy

Volume 12 , Issue 2 , 2017

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Cardiovascular diseases remain the leading cause of mortality or disabled quality of life for people over the world. The necessity of neovascularization is essential for re-establishing the tissue functions after a major lesion that occurs in patients with cardiovascular disorders, such as ischemia, atherosclerosis, diabetes, peripheral vascular disease and burn wounds. This review focuses on the recent data regarding the polymers and scaffolds that are used for improving neovascularization with emphasis on the biocompatibility and mechanisms involved in stem cells proliferation, migration, adherence, differentiation and organization in vascular networks. The newly emerging techniques used in conjugation of synthetic polymers with polysaccharides or proteins attempt to improve the biocompatibility of scaffolds, but the complex structures of blood vessels make their construction to remain a major challenge for the vascular tissue engineering.

Keywords: Bioprinter, natural polymers, neovascularization, stem cells, synthetic polymers.

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Article Details

Year: 2017
Published on: 03 December, 2015
Page: [155 - 164]
Pages: 10
DOI: 10.2174/1574888X11666151203223658
Price: $65

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PDF: 37