Clinical Features, Medical Issues, and Diagnostic Testing in Angelman Syndrome
Pp. 3-27 (25)
Jennifer M. Mueller,
Charles A. Williams
This chapter reviews the clinical and medical aspects of Angelman
syndrome (AS) and the genetic mechanisms that create a deficiency of the function of
UBE3A on the maternally-derived number 15 chromosome. Genetic mechanisms
causing AS include cytogenetic deletions, imprinting center defects, paternal
uniparental disomy and UBE3A mutations. We review the clinical criteria for the
diagnosis of AS and discuss genetic confirmatory testing. The chapter explores the
natural history and characteristic features of AS including severe developmental delay,
speech impairment, gait ataxia, microcephaly, seizures, and unique behaviors. Finally,
we will discuss the implications for learning and overall function.
Angelman syndrome, Behavior phenotype, Chromosome disorder,
Chromosome 15, Developmental delay, Genetic imprinting, Intellectual
deficiency, Neurogenetics, UBE3A gene.