Title:Freezing of Gait in Parkinsonism and its Potential Drug Treatment
VOLUME: 14 ISSUE: 4
Author(s):Li-Li Zhang, S. Duff Canning and Xiao-Ping Wang
Affiliation:Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao-Tong University, China. 200080.
Keywords:Drug treatment, freezing of gait, Levodopa, Parkinson’s disease, Parkinsonism.
Abstract:Freezing of gait (FOG) is a heterogeneous symptom. Studies of treatment for FOG are
scarce. Levodopa and monoamine oxidase inhibitors (rasagiline and selegiline) have shown effective
improvement for FOG. Other drugs, such as L-threo-3, 4-dihydroxyphenylserine, amantadine, and
botulinum toxin have exhibited some beneficial effects. The present review summarizes the potential
drug treatment for FOG in Parkinsonism.
