Recent Advances in Medicinal Chemistry

Volume: 2

Indexed in: EBSCO.

Recent Advances in Medicinal Chemistry is a book series focused on leading-edge research on developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, ...
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Updated Report on Synthesis and Biological Properties of Oxadiazine-Based Heterocyclic Derivatives

Pp. 107-143 (37)

Xiufang Cao and Shaoyong Ke


Oxadiazine scaffold-based compounds are undoubtedly an important class of heterocyclic derivatives, which always present diverse bioactivities including cardiovascular, antitumor, antiviral, anti-leishmanial, antibacterial, antimicrobial, monoamine oxidase inhibition, acricidal, insecticidal, plant-growth regulating activities and chitin biosynthesis inhibitions. With the development of organic synthesis, versatile features of oxadiazine ring have emerged, so here we have reviewed the recent advances of oxadiazine-based heterocyclic derivatives mainly including preparation, transformation and biological properties, and this report is also an updated version of our previous review with modifications.


Oxadiazine, oxadiazinone, heterocyclic scaffold, synthetic method, pharmaceutical activity, pesticidal activity, biological application.


National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan 430064, People`s Republic of China.