Interfacial Fast Release Layer in Monodisperse Poly (lactic-co-glycolic acid) Microspheres Accelerates the Drug Release

Author(s): Jun Wu, Xiaoli Zhao, Kelvin W.K. Yeung, Michael K.T. To

Journal Name: Current Drug Delivery

Volume 13 , Issue 5 , 2016

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Understanding microstructural evolutions of drug delivery devices during drug release process is essential for revealing the drug release mechanisms and controlling the drug release profiles. In this study, monodisperse poly (lactic-co-glycolic acid) microspheres in different diameters were fabricated by microfluidics in order to find out the relationships between the microstructural evolutions and the drug release profiles. It was found that poly (lactic-co-glycolic acid) microspheres underwent significant size expansion which took place from the periphery to the center, resulting in the formation of interfacial fast release layers. At the same time, inner pores were created and the diffusion rate was increased so that the early stage drug release was accelerated. Due to the different expansion rates, small poly (lactic-co-glycolic acid) microspheres tendered to follow homogeneous drug release while large poly (lactic-co-glycolic acid) microspheres tendered to follow heterogeneous drug release. This study suggests that the size expansion and the occurrence of interfacial fast release layer were important mechanisms for early stage drug release of poly (lactic-co-glycolic acid) microspheres.

Keywords: Controlled drug delivery, drug release mechanism, interfacial fast release layer, microfluidics, microstructural evolution, PLGA microspheres.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 5
Year: 2016
Page: [720 - 729]
Pages: 10
DOI: 10.2174/1567201813666151130221030
Price: $65

Article Metrics

PDF: 24
HTML: 3