In the article authors discuss the current data on sleep changes with aging focusing on the
influence of age-related degenerative changes in orexin-containing and pacemaker brain areas. Pathophysiological
mechanisms of sleep disturbances in Parkinson’s and Alzheimer’s diseases have much
in common with normal age neurophysiological changes. Maintenance of the sleep-promoting systems
function could positively modify the course of these diseases.
Keywords: Age, Alzheimer’s disease, Parkinson’s disease, sleep, orexins, sleep disorders.
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