Cell Bystander Effect Induced by Radiofrequency Electromagnetic Fields and Magnetic Nanoparticles

Author(s): M. P. Calatayud, L. Asin, A. Tres, G. F. Goya, M. R. Ibarra

Journal Name: Current Nanoscience

Volume 12 , Issue 3 , 2016

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Abstract:

Induced effects by direct exposure to ionizing radiation (IR) are a central issue in many fields like radiation protection, clinic diagnosis and oncological therapies. Direct irradiation at certain doses induce cell death, but similar effects can also occur in cells no directly exposed to IR, a mechanism known as bystander effect. Non-IR radiofrequency waves can induce the death of cells loaded with MNPs in a focused oncological therapy known as magnetic hyperthermia. Indirect mechanisms are also able to induce the death of unloaded MNPs cells. Using in vitro cell models, we found that co-localization of the MNPs at the lysosomes and the non-increase of the temperature induces bystander effect under non-IR. Our results provide a landscape in which bystander effects are a more general mechanism, up to now only observed and clinically used in the field of radiotherapy.

Keywords: Bystander effect, ionizing radiation, magnetic nanoparticles, magnetic hyperthermia.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2016
Page: [372 - 377]
Pages: 6
DOI: 10.2174/1573413712666151124195846
Price: $65

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