Induced effects by direct exposure to ionizing radiation (IR) are a central issue in many
fields like radiation protection, clinic diagnosis and oncological therapies. Direct irradiation at certain
doses induce cell death, but similar effects can also occur in cells no directly exposed to IR, a mechanism
known as bystander effect. Non-IR radiofrequency waves can induce the death of cells loaded
with MNPs in a focused oncological therapy known as magnetic hyperthermia. Indirect mechanisms
are also able to induce the death of unloaded MNPs cells. Using in vitro cell models, we found that co-localization of the
MNPs at the lysosomes and the non-increase of the temperature induces bystander effect under non-IR. Our results provide
a landscape in which bystander effects are a more general mechanism, up to now only observed and clinically used in
the field of radiotherapy.
Keywords: Bystander effect, ionizing radiation, magnetic nanoparticles, magnetic hyperthermia.
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