Due to core-shell nanostructures, highly branched and star-shaped macromolecules
with three dimensional structural symmetry, dendrimers have been widely used as non-viral vectors in gene delivery. However, the performance
of dendrimer-based gene vectors is far from ideal, mainly because of the low transfection efficiency and serious cytotoxicity.
Therefore, many researchers focused on how to improve the transfection efficiency and reduce the cytotoxicity in the past decade. In this
review, we mainly reported the most recent advances of dendrimer-based gene delivery systems. Several typical types of dendrimers for
gene delivery were reviewed in detail, such as poly (amido amine) (PAMAM), poly (propylene imine) (PPI), poly(ether imine), poly-Llysine
dendrimers. Recent advances about other types of dendrimer were also briefly mentioned. These advances provide a promising
route to improve the transfection efficiency and reduce the toxicity, which also illustrates the direction of the future development of dendrimers
in gene delivery.