Title:The Pathophysiology of Heart Failure in Children: The Basics
VOLUME: 12 ISSUE: 2
Author(s):Jarrod D. Knudson and Antonio G. Cabrera
Affiliation:Division of Critical Care Medical Children's of Mississippi / Blair E. Batson Hospital for Children University of Mississippi Medical Center Office 2500 N State St Jackson, Mississipi, 39216, United States of America
Keywords:Diastolic dysfunction, heart failure, neurohormonal activation, pediatrics, systolic dysfunction,
ventricular remodeling.
Abstract:Few data exist on the pathophysiologic changes in pediatric heart failure. Most of the
knowledge has evolved from animal models of ischemic or idiopathic dilated cardiomyopathy. This
review addresses the pathophysiologic changes that occur in the failing heart from animal models and
the adult experience to unique aspects of heart failure in children.
