The activity dependent brain repair mechanism has been widely adopted in many types of neurorehabilitation.
The activity leads to target specific and non-specific beneficial effects in different brain regions, such as the releasing of
neurotrophic factors, modulation of the cytokines and generation of new neurons in adult hood. However physical
exercise program clinically are limited to some of the patients with preserved motor functions; while many patients
suffered from paralysis cannot make such efforts. Here the authors proposed the employment of mirror neurons system in
promoting brain rehabilitation by “observation based stimulation”. Mirror neuron system has been considered as an
important basis for action understanding and learning by mimicking others. During the action observation, mirror neuron
system mediated the direct activation of the same group of motor neurons that are responsible for the observed action. The
effect is clear, direct, specific and evolutionarily conserved. Moreover, recent evidences hinted for the beneficial effects
on stroke patients after mirror neuron system activation therapy. Finally some music-relevant therapies were proposed to
be related with mirror neuron system.
Keywords: Mirror neuron system, brain stimulation, neurorehabilitation, stroke.
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