Abstract
Physical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocytesecreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity. The present review introduces the previously-reported functions of adult hippocampal neurogenesis and adiponectin, and discusses the potential relevance of adiponectin signaling in exercise-induced neural changes. Revealing these novel biological effects of adiponectin in the brain may help hunt reliable biomarkers to better guide the anti-depressive therapy with exercise intervention; meanwhile, pharmaceutical agents that raise endogenous levels of adiponectin or mimic its biological effects might serve as a replacement for physical exercise.
Keywords: Adult neurogenesis, hippocampus, adiponectin, depression, physical exercise.
CNS & Neurological Disorders - Drug Targets
Title:Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise
Volume: 14 Issue: 9
Author(s): Ang Li, Suk-Yu Yau, Sergio Machado, Ti-Fei Yuan and Kwok-Fai So
Affiliation:
Keywords: Adult neurogenesis, hippocampus, adiponectin, depression, physical exercise.
Abstract: Physical exercise has long been recognized to benefit locomotor and cardiovascular systems. Although an increasing body of evidence also suggests it to be an effective non-medicinal remedy for mental disorders such as depression, the underlying mechanisms remain elusive. A recent study has demonstrated that increases of the adipocytesecreted hormone adiponectin in the central nervous system following exercise may be responsible for these neuropsychological changes, including enhanced generation of neurons in the adult hippocampus, as well as mitigation of depressive severity. The present review introduces the previously-reported functions of adult hippocampal neurogenesis and adiponectin, and discusses the potential relevance of adiponectin signaling in exercise-induced neural changes. Revealing these novel biological effects of adiponectin in the brain may help hunt reliable biomarkers to better guide the anti-depressive therapy with exercise intervention; meanwhile, pharmaceutical agents that raise endogenous levels of adiponectin or mimic its biological effects might serve as a replacement for physical exercise.
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Cite this article as:
Li Ang, Yau Suk-Yu, Machado Sergio, Yuan Ti-Fei and So Kwok-Fai, Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise, CNS & Neurological Disorders - Drug Targets 2015; 14 (9) . https://dx.doi.org/10.2174/1871527315666151111125533
DOI https://dx.doi.org/10.2174/1871527315666151111125533 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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