The pathophysiology of depression is related to neurobiological changes that occur in the monoamine system,
hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a
growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brainderived
neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review
investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression.
It was not possible to establish an interaction between aerobic exercise and concentration of BDNF and cortisol, which
may actually be the result of the divergence of methods, such as type of exercises, duration of the sessions, and prescribed
intensity and frequency of sessions.