Acid-sensing ion channels (ASICs) are scattered various cells of human body.
Drugs like amiloride has demonstrated nonspecific antagonism ASICs. Toxins, such as
Psalmotoxin-1, have been used in animal models. There are no drugs available in the market
whose action mechanism acts through these channels. We revised all patents relating to
pharmaceutical formulations of applicability in ASICs. Drugs acting as antagonist in ASIC1 or ASIC3 channels
seem to be the most promising targets. Patent data have suggested a variety of approaches for selective
ASICs drugs, such as neuroprotective and analgesic. Studies analysis suggested that ASICs are promising targets
for new drugs.
Keywords: ASIC, antagonist, drugs, review, patent, pain, inflammation.
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