To evaluate the effect of moderate intensity of aerobic exercise on elderly people with mild Alzheimer’s
disease, we recruited fifty volunteers aged 50 years to 80 years with cognitive impairment. They were randomized into
two groups: aerobic group (n=25) or control group (n=25). The aerobic group was treated with cycling training at 70% of
maximal intensity for 40 min/d, 3 d/wk for 3 months. The control group was only treated with heath education. Both
groups were received cognitive evaluation, laboratory examination before and after 3 months. The results showed that the
Minimum Mental State Examination score, Quality of Life Alzheimer’s Disease score and the plasma Apo-a1 level was
significantly increased (P<0.05), the Alzheimer’s Disease Assessment Scale-cognition score, Neuropsychiatric Inventory
Questionnaire score was significantly decreased(P<0.05) in aerobic group before and after 3 months in aerobic group.
For the control group, there was no significant difference in scores of Alzheimer’s Disease Assessment Scale-cognition,
Neuropsychiatric Inventory Questionnaire, Quality of Life Alzheimer’s Disease, Apo-a1 (P>0.05), while Minimum
Mental State Examination scores decreased significantly after 3 months (P<0.05). In conclusion, moderate intensity of
aerobic exercise can improve cognitive function in patients with mild Alzheimer’s disease.