Alterations in myocardial metabolism and blood flow have been described in patients
with metabolic disorders, cardiovascular disease and cardiomyopathies, and have been implicated
in the pathogenesis or prognosis of cardiac conditions. Adipose tissue dysfunction occurs in the
above categories of patients. Adipose tissue plays a fundamental role in the modulation and selection
of nutrients reaching the myocardium, and adipocytes secrete adipokines and other molecules
affecting myocardial metabolism and regulating vascular function. In turn, the myocardium
secretes a series of peptides affecting adipose tissue metabolism, and adipose tissue vascularization
and perfusion contribute to the maintenance of adipose tissue health. This review addresses
the reciprocal interaction linking adipose tissue to myocardial metabolism and vascular function.
We summarize evidence of factors released by adipose tissue that affect cardiac metabolism and
vice versa. Then, we address the role of adipose tissue in regulating vascular health, and examine whether adipose tissue hypoperfusion is
causative or defensive of adipose tissue dysfunction.
Keywords: Fatty acids, natriuretic peptides, hypoxia, adiponectin, obesity, cardiovascular disease.
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