Cardiovascular Implantable Electronic Device Infections: Risk Scoring and Role of Antibiotic Envelope in Prevention

Author(s): Nasir Shariff, Tauseef Akthar, Eathar Razak, Nathan Segerson, David Schwartzman

Journal Name: Recent Advances in Cardiovascular Drug Discovery (Discontinued)
Formerly Recent Patents on Cardiovascular Drug Discovery

Volume 10 , Issue 1 , 2015

Graphical Abstract:


Cardiac implantable electronic device (CIED) has been increasingly used with expanding indications in patients with cardiac diseases. There is substantial evidence to suggest of their role in improving outcomes in patients with and without heart failure. Complications of the device implantation including infections are associated with increased morbidity and mortality and also substantial financial burden to the society. Several clinical characteristics have been recognized as risk factors for the occurrence of the infections. Considering that infections occur in the presence of multiple risk factors acting together, scoring systems have been developed in identifying patients at risk. Despite preventive measures, the rates of infections associated with CIEDs have increased over the last decade. Recent studies have documented the role of implantable antibiotic eluting pouches in reducing infections in patients undergoing CIED implantation. The present review will address the risk scoring systems studied and also address the role of antibiotic pouch and the recent patents in developing this technology.

Keywords: Antibiotic, cardiovascular, cardiac implantable electronic device, cardiac diseases, epidemiology, infections.

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Article Details

Year: 2015
Published on: 11 January, 2016
Page: [70 - 76]
Pages: 7
DOI: 10.2174/1574890110666151104120207

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