Tetrazine Bioorthogonal Reaction: A Novel Scheme for Polymer and Biomaterials

Author(s): Hongyan Zhu, Haoxing Wu, Min Wu, Qiyong Gong

Journal Name: Current Organic Chemistry

Volume 20 , Issue 17 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Bioorthogonal reactions have been widely used on live-cell labeling, animal tissue imaging, drug delivery, and biomaterials in the recent ten years. Tetrazine bioorthogonal chemistry is not only orthogonal with biological system, other click chemistry and traditional polymer chemistry, but also has superb kinetics, generates biocompatibility products, and proceeds under mild reaction condition. All these features enable tetrazine bioorthogonal chemistry to be widely applied to polymer and biomaterial science. Recently there are many exciting accomplishments. This chemistry can act as an ideal method for polymer and nanoparticle modification, a desired vehicle for nanoparticles in vivo delivery, new polymerization strategy, and novel hydrogel formation platform. In this review, we introduce recent advancements in biomaterials based on tetrazine bioorthogonal chemistry.

Keywords: Bioorthogonal chemistry, tetrazine, polymer, biomaterials, nanoparticles.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Page: [1756 - 1767]
Pages: 12
DOI: 10.2174/1385272820666151102212821
Price: $65

Article Metrics

PDF: 38
PRC: 1