AMPK Function in Aging Process

Author(s): Rocío Ruiz, Eva María Pérez-Villegas, Ángel Manuel Carrión

Journal Name: Current Drug Targets

Volume 17 , Issue 8 , 2016

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Aging involves the progressive deterioration of physiological functions, diminishing the individual’s capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved genetic and biochemical pathways represented an unprecedented advance in aging research. The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.

Keywords: AMPK, aging, metabolic dysfunction, stress oxidative, senescence.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 01 November, 2015
Page: [932 - 941]
Pages: 10
DOI: 10.2174/1389450116666151102095825
Price: $65

Article Metrics

PDF: 76
PRC: 1