Aging involves the progressive deterioration of physiological functions, diminishing the individual’s
capacity for survival. Indeed, aging is the main risk factor for cancer, diabetes, cardiovascular
disorders and neurodegenerative diseases. The discovery that the rate of aging is controlled by conserved
genetic and biochemical pathways represented an unprecedented advance in aging research.
The AMPK protein is a metabolic sensor that acts as a qualified cellular housekeeper, as well as controlling
energy homeostasis and resistance to stress. Thus, the correct regulation of this factor enhances
health and survival. In this manuscript we will review the molecular pathways regulated by AMPK that are related to the
aging process, paying special attention to mitochondrial dysfunction, metabolic deregulation, cell senescence and autophagy.