Abstract
New hollow fiber based liquid phase microextraction (HF-LPME) technique followed by high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detector was introduced for detection and determination of terazosin in urine and plasma samples. The effect of different parameters which influence extraction efficiency such as organic membrane solvent, donor/acceptor phase composition, extraction time, stirring rate, salt concentration and extraction temperature were studied. Following optimization, extraction recoveries more than 86% were obtained in different biological matrices which resulted in preconcentration factors higher than 161 and an acceptable repeatability (1.25 < RSD% <2.30, n=3). The method presents good linearity with coefficiency higher than 0.9994. Finally, the proposed method was applied for detection and determination of terazosin in urine and plasma samples.
Keywords: High performance liquid chromatography, hollow fiber liquid phase microextraction, terazosin, microextraction.
Current Analytical Chemistry
Title:Three-phase Hollow fiber Liquid-phase Micro Extraction for Determination and Analysis of Terazosin in Biological Fluids Via High Performance Liquid Chromatography at Trace Levels
Volume: 12 Issue: 5
Author(s): Sahel Emadzadeh, Mahnaz Qomi, Mohammadreza Saadat and Foroozan Piroozi
Affiliation:
Keywords: High performance liquid chromatography, hollow fiber liquid phase microextraction, terazosin, microextraction.
Abstract: New hollow fiber based liquid phase microextraction (HF-LPME) technique followed by high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detector was introduced for detection and determination of terazosin in urine and plasma samples. The effect of different parameters which influence extraction efficiency such as organic membrane solvent, donor/acceptor phase composition, extraction time, stirring rate, salt concentration and extraction temperature were studied. Following optimization, extraction recoveries more than 86% were obtained in different biological matrices which resulted in preconcentration factors higher than 161 and an acceptable repeatability (1.25 < RSD% <2.30, n=3). The method presents good linearity with coefficiency higher than 0.9994. Finally, the proposed method was applied for detection and determination of terazosin in urine and plasma samples.
Export Options
About this article
Cite this article as:
Emadzadeh Sahel, Qomi Mahnaz, Saadat Mohammadreza and Piroozi Foroozan, Three-phase Hollow fiber Liquid-phase Micro Extraction for Determination and Analysis of Terazosin in Biological Fluids Via High Performance Liquid Chromatography at Trace Levels, Current Analytical Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573411012666151030212948
DOI https://dx.doi.org/10.2174/1573411012666151030212948 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Analytical methods for environmental and food analysis
In recent years, the study of the chemical composition of food and the environment depends on analytical methods in order to acquire information about the chemical composition, processing, quality control and contamination of soil, water, air, plants and foods, aspects very important for food safety and environmental quality control. There ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
Bioanalytical and Biosensor Technologies for Target Molecules
Bioanalytical and biosensor technologies constitute the core of detecting and sensing diverse molecules within living organisms, encompassing proteins, DNA, small molecular metabolites, and beyond. These molecules assume pivotal roles in biological processes, rendering their analysis and sensing indispensable for comprehending biological phenomena and unraveling disease mechanisms. In the current landscape ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Brain Angiotensinergic Regulation of the Immune System: Implications for Cardiovascular and Neuroendocrine Responses
Endocrine, Metabolic & Immune Disorders - Drug Targets Non-Steroidal Anti-Inflammatory Drugs used as a Treatment Modality in Subarachnoid Hemorrhage
Current Drug Safety Sesamin and Sesamolin: Natures Therapeutic Lignans
Current Enzyme Inhibition Neuronal Histamine and its Receptors: Implication of the Pharmacological Treatment of Obesity
Current Medicinal Chemistry G Protein-Coupled Receptor Kinase 2 - a Feedback Regulator of Gq Pathway Signalling
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Phosphodiasterase 5-Inhibitors (PDE-5i) for Erectile Dysfunction (ED): A Therapeutic Challenge For Psychiatrists
Current Drug Targets Metabolic Syndrome and Cardiometabolic Risk Factors
Current Vascular Pharmacology The Pathophysiological Basis of Renal Nerve Ablation for the Treatment of Hypertension
Current Vascular Pharmacology Study on the Effect of HPMC on Compression Coated Floating Pulsatile Delivery of Bisoprolol
Current Drug Therapy Commentary ( The Renin Angiotensin System in Alzheimers Disease - Do Updates Highlight a Clinical and Biological Dichotomy? )
Current Alzheimer Research A Comprehensive Review on Exosomes and Microvesicles as Epigenetic Factors
Current Stem Cell Research & Therapy Anti-Inflammatory Role of Thyroid Hormones on Rat Air Pouch Model of Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Role of Heat Shock Proteins in Atherosclerosis and Atrial Fibrillation
Current Immunology Reviews (Discontinued) Activation of the Renin-angiotensin System could Cause Hypertension During Fasting in Muslims in the Month of Ramadhan
Current Hypertension Reviews Visceral Fat as Target of Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome
Current Pharmaceutical Design Ivabradine: Cardiovascular Effects
Recent Patents on Cardiovascular Drug Discovery The Cellular Effects of Carbon Monoxide in the Airway
Current Molecular Medicine Preterm Labour: An Overview of Current and Emerging Therapeutics
Current Medicinal Chemistry Pharmacology of Adenosine A2A Receptors and Therapeutic Applications
Current Topics in Medicinal Chemistry Endothelial Dysfunction, Impaired Endogenous Platelet Inhibition and Platelet Activation in Diabetes and Atherosclerosis
Current Vascular Pharmacology