Alpha-Synuclein is found in the neuronal cells but its native function is not well known.
While α -synuclein is an intrinsically disordered protein that adopts a helical conformation upon
membrane binding, numerous studies have shown that oligomeric β-forms of this protein are
cytotoxic. This response to misfolded species contributes to Parkinson’s Disease etiology and
symptoms. The resulting amyloid fibrils are an established diagnostic in Parkinson’s Disease. In this
review, we focus on strategies that have been used to inhibit the amyloidogenesis of α -synuclein
either by stabilizing the native state, or by redirecting the pathway to less toxic aggregates. Small
molecules such as polyphenols, peptides as well as large proteins have proven effective at protecting
cells against the cytotoxicity of α-synuclein. These strategies may lead to the development of therapeutic agents that could
prove useful in combating this disease.
Keywords: Amyloidogenesis, antibodies, Parkinson’s Disease, polyphenol, proteins, α-synuclein.
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