Abstract
Currently, the treatment for HBV infection suffers from adverse side effects and drug resistance. The dramatic development of new HBV inhibitors is focused on discovering diverse non-nucleoside compounds with either novel structures or new mechanisms of action. Capsid assembly is crucial to the completion of the viral life cycle, which makes it an attractive target for antivirus discovery. Inhibitors that block the formation of the HBV capsid have been developed, and several candidates have been proposed. In this review, we focus on the recent advances in several distinct classes of synthetic small molecular non-nucleosides targeting at the capsid assembly.
Keywords: HBV, inhibitors, non-nucleosides, small synthetic molecules, capsid assembly.
Medicinal Chemistry
Title:Review of Small Synthetic Molecules Targeting HBV Capsid Assembly
Volume: 11 Issue: 8
Author(s): Na Liu, Fabao Zhao, Peng Zhan and Xinyong Liu
Affiliation:
Keywords: HBV, inhibitors, non-nucleosides, small synthetic molecules, capsid assembly.
Abstract: Currently, the treatment for HBV infection suffers from adverse side effects and drug resistance. The dramatic development of new HBV inhibitors is focused on discovering diverse non-nucleoside compounds with either novel structures or new mechanisms of action. Capsid assembly is crucial to the completion of the viral life cycle, which makes it an attractive target for antivirus discovery. Inhibitors that block the formation of the HBV capsid have been developed, and several candidates have been proposed. In this review, we focus on the recent advances in several distinct classes of synthetic small molecular non-nucleosides targeting at the capsid assembly.
Export Options
About this article
Cite this article as:
Liu Na, Zhao Fabao, Zhan Peng and Liu Xinyong, Review of Small Synthetic Molecules Targeting HBV Capsid Assembly, Medicinal Chemistry 2015; 11 (8) . https://dx.doi.org/10.2174/157340641108151029111243
DOI https://dx.doi.org/10.2174/157340641108151029111243 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Advances in the Signal Transduction Targeting of Colorectal Cancer: The Paradigm of Translational Medicine
Current Signal Transduction Therapy Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents: Potential Anticancer Drugs
Current Molecular Medicine Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma
Current Pharmaceutical Biotechnology Biological Modulation by Lectins and Their Ligands in Tumor Progression and Metastasis
Anti-Cancer Agents in Medicinal Chemistry Surface Antigens/Receptors for Targeted Cancer Treatment: The GnRH Receptor / Binding Site for Targeted Adenocarcinoma Therapy
Current Cancer Drug Targets Angiogenesis Inhibitors: Implications for Combination with Conventional Therapies
Current Pharmaceutical Design Effect and Mechanism of the Lenvatinib@H-MnO<sub>2</sub>-FA Drug Delivery System in Targeting Intrahepatic Cholangiocarcinoma
Current Pharmaceutical Design Selection and Characterization of Human Anti-MAGE-A1 scFv and Immunotoxin
Anti-Cancer Agents in Medicinal Chemistry The Immunoproteasome: An Emerging Therapeutic Target
Current Topics in Medicinal Chemistry Intracellular Trafficking of MDR Transporters and Relevance of SNPs
Current Topics in Medicinal Chemistry Cytotoxic and Radio-sensitizing Effects of Polyphenolic Acetates in a Human Glioma Cell Line (BMG-1)
Current Pharmaceutical Design The Promise of miRNA Replacement Therapy for Hepatocellular Carcinoma
Current Gene Therapy Anti-Respiratory Syncytial Virus Mechanism of <i>Houttuynia cordata</i> Thunb Exploration based on Network Pharmacology
Combinatorial Chemistry & High Throughput Screening Imaging Studies in Hypercalcemia
Current Medicinal Chemistry High-throughput Screening Identifies Small Molecule Inhibitors of Molecular Chaperones
Current Pharmaceutical Design Angiopoietin-2 Axis Inhibitors: Current Status and Future Considerations for Cancer Therapy
Current Angiogenesis (Discontinued) Doxorubicin vs. ladirubicin: methods for improving osteosarcoma treatment
Mini-Reviews in Medicinal Chemistry Preparation and Characterization of Nanoemulsome Entrapped in Enteric Coated Hydrogel Beads for the Controlled Delivery of Capsaicin to the Colon
Current Drug Therapy Vascular Endothelial Growth Factor Receptors [VEGFR] as Target in Breast Cancer Treatment: Current Status in Preclinical and Clinical Studies and Future Directions
Current Topics in Medicinal Chemistry Alpha-1-Antitrypsin Deficiency Liver Disease and New Treatment Opportunities
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry