Abstract
Hypersensitivity pneumonitis is a form of interstitial lung disease caused by a wide array of respirable particles. Given the widespread prevalence of many implicated exposures, contributing factors such as genetic predisposition and concomitant environmental factors likely influence the risk of disease development. Common causes include a range of bacterial and fungal species, and a number of chemical exposures such as to isocyanates. Exposures to microbial contaminants can occur in a range of domestic, recreational and occupational settings. Occupational exposures to microbial contamination include and are not limited to the farming industry, the manufacturing industry which frequently requires the use of metalworking fluids, and the food industry. Diagnostic assessment initially relies on a high index of clinical suspicion. Subsequent workup integrates clinical history, pulmonary function testing and radiologic imaging with a high resolution chest CT scan. In certain clinical scenarios, serological testing, bronchoscopy with bronchoalveolar lavage and/or surgical lung biopsy may be informative.
Keywords: Hypersensitivity pneumonitis, extrinsic allergic alveolitis, interstitial dung disease, farmer’s lung, hot tub lung, summer-type hypersensitivity pneumonitis, isocyanates, specific inhalation challenge testing.
Current Respiratory Medicine Reviews
Title:An Update on Hypersensitivity Pneumonitis
Volume: 12 Issue: 1
Author(s): Mridu Gulati
Affiliation:
Keywords: Hypersensitivity pneumonitis, extrinsic allergic alveolitis, interstitial dung disease, farmer’s lung, hot tub lung, summer-type hypersensitivity pneumonitis, isocyanates, specific inhalation challenge testing.
Abstract: Hypersensitivity pneumonitis is a form of interstitial lung disease caused by a wide array of respirable particles. Given the widespread prevalence of many implicated exposures, contributing factors such as genetic predisposition and concomitant environmental factors likely influence the risk of disease development. Common causes include a range of bacterial and fungal species, and a number of chemical exposures such as to isocyanates. Exposures to microbial contaminants can occur in a range of domestic, recreational and occupational settings. Occupational exposures to microbial contamination include and are not limited to the farming industry, the manufacturing industry which frequently requires the use of metalworking fluids, and the food industry. Diagnostic assessment initially relies on a high index of clinical suspicion. Subsequent workup integrates clinical history, pulmonary function testing and radiologic imaging with a high resolution chest CT scan. In certain clinical scenarios, serological testing, bronchoscopy with bronchoalveolar lavage and/or surgical lung biopsy may be informative.
Export Options
About this article
Cite this article as:
Gulati Mridu, An Update on Hypersensitivity Pneumonitis, Current Respiratory Medicine Reviews 2016; 12 (1) . https://dx.doi.org/10.2174/1573398X11666151028205804
DOI https://dx.doi.org/10.2174/1573398X11666151028205804 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Regulation and Function of DNA and Histone Methylations
Current Pharmaceutical Design The History, Mechanism and Clinical Use of Oral 5-Fluorouracil Derivative Chemotherapeutic Agents
Current Pharmaceutical Biotechnology Different Aspects of Head and Neck Squamous Cell Carcinoma: Cancer Stem Cells, their Niche and Targeted Therapy
Current Stem Cell Research & Therapy Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings
Letters in Organic Chemistry Cheminfomatic-based Drug Discovery of Human Tyrosine Kinase Inhibitors
Current Topics in Medicinal Chemistry Autophagy Driven Extracellular Vesicles in the Leukaemic Microenvironment
Current Cancer Drug Targets Nuclear Export Mediated Regulation of MicroRNAs: Potential Target for Drug Intervention
Current Drug Targets Advances in Nano Drugs for Cancer Chemotherapy
Current Cancer Drug Targets Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models
Current Neuropharmacology Bioinformatics Tools for Mass Spectrometry-Based High-Throughput Quantitative Proteomics Platforms
Current Proteomics A Review on Onychine and its Analogs: Synthesis and Biological Activity
Current Organic Synthesis Corticotropin Releasing Factor (CRF) Peptide Family and their Receptors: Divergent Actions Influencing Human Physiology
Current Genomics Surface Plasmon Resonance Imaging Sensor for Cathepsin Determination Based on Immobilized Cystatin
Protein & Peptide Letters Recent Advances in c-Jun N-Terminal Kinase (JNK) Inhibitors
Current Medicinal Chemistry Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
Letters in Drug Design & Discovery A Disposable, Highly Sensitive Biosensing System: Determination of Haptoglobin as a Significant Acute Phase Biomarker
Current Analytical Chemistry Intraorganellar Acidification by V-ATPases: A Target in Cell Proliferation and Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Anticancer Drug Discovery Targeting DNA Hypermethylation
Current Medicinal Chemistry Biosafety Challenges for Use of Lentiviral Vectors in Gene Therapy
Current Gene Therapy Current Status and Perspectives in Peptide Receptor Radiation Therapy
Current Pharmaceutical Design