Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death

Author(s): O. Florey, S. E. Kim, M. Overholtzer

Journal Name: Current Molecular Medicine

Volume 15 , Issue 9 , 2015

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Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial cell cultures and human tumors. Entotic cells control their own engulfment, by invading into their hosts in a Rho-GTPase and actomyosin-dependent manner. Although entotic cells are internalized while alive, most eventually undergo a non-apoptotic form of cell death, called entotic cell death, that is executed non-cell-autonomously by autophagy proteins and lysosomes. Here we review the current understanding of entosis and entotic cell death and discuss the potential roles of this process in cancer.

Keywords: Cell-in-cell, entosis, entotic cell death, cannibalism, phagocytosis, engulfment, autophagy, LAP, cell competition.

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Article Details

Year: 2015
Published on: 25 October, 2015
Page: [861 - 866]
Pages: 6
DOI: 10.2174/1566524015666151026100042
Price: $65

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