Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents

Author(s): Liliana Lucescu, Elena Bîcu, Dalila Belei, Joelle Dubois, Alina Ghinet

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 6 , 2016

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Abstract:

A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC50 = 1.07 ± 0.34 µM) and could represent a lead for the development of new antitumoral chemical entities.

Keywords: Indolizine, farnesyltransferase, anticancer agent.

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Article Details

VOLUME: 13
ISSUE: 6
Year: 2016
Page: [479 - 488]
Pages: 10
DOI: 10.2174/1570180812666151022221628
Price: $65

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