Title:Design of Fucoidan Functionalized - Iron Oxide Nanoparticles for Biomedical Applications
VOLUME: 13 ISSUE: 5
Author(s):Khanh Nghia Tran, Phuong Ha-Lien Tran, Toi Van Vo and Thao Truong-Dinh Tran
Affiliation:Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University – Ho Chi Minh City, Vietnam.
Keywords:Curcumin, Fucoidan, Iron oxide nanoparticles, Paclitaxel, Ultrasonication.
Abstract:This research aims to develop an iron oxide nanoparticle drug delivery system
utilizing a recent material discovered from ocean, fucoidan. The material has
drawn much interest due to many biomedical functions that have been proven for human
health. One interesting point herein is that fucoidan is not only a sulfated polysaccharide,
a polymer for stabilization of iron oxide nanoparticles, but plays a role of an anticancer agent also. Various approaches
were investigated to optimize the high loading efficiency and explain the mechanism of nanoparticle formations.
Fucoidan was functionalized on iron oxide nanoparticles by a direct coating or via amine groups. Also, a hydrophobic part
of oleic acid was conjugated to the amine groups for a more favorable loading of poorly water-soluble anticancer drugs.
This study proposed a novel system and an efficient method to functionalize fucoidan on iron oxide nanoparticle systems
which will lead to a facilitation of a double strength treatment of cancer.
