Abstract
With ever-increasing drug resistant clinical isolates, novel antibiotics with new targets are urgently needed. Tuberculosis, caused by Mycobacterium tuberculosis, showed formidable antibiotics resistance. InhA, the enoyl-acyl carrier protein (ACP) reductase involved in the type II fatty acid synthesis pathway (FASII) in Mycobacterium tuberculosis, represents an appealing target for the development of new anti-tuberculosis (TB) agents. Inhibitors against InhA might be ideal lead or antibiotics. The latest development of InhA inhibitors is summarized in this paper.
Keywords: Drug discovery, drug resistance, enoyl-ACP reductase, InhA, isoniazid, tuberculosis.
Letters in Drug Design & Discovery
Title:Progress on the Discovery of Inhibitors of InhA, the FAS II Enoyl-ACP Reductase TB Drug Discovery Targeted on InhA
Volume: 13 Issue: 6
Author(s): Yi Zhang, Longxiang Xie and Jianping Xie
Affiliation:
Keywords: Drug discovery, drug resistance, enoyl-ACP reductase, InhA, isoniazid, tuberculosis.
Abstract: With ever-increasing drug resistant clinical isolates, novel antibiotics with new targets are urgently needed. Tuberculosis, caused by Mycobacterium tuberculosis, showed formidable antibiotics resistance. InhA, the enoyl-acyl carrier protein (ACP) reductase involved in the type II fatty acid synthesis pathway (FASII) in Mycobacterium tuberculosis, represents an appealing target for the development of new anti-tuberculosis (TB) agents. Inhibitors against InhA might be ideal lead or antibiotics. The latest development of InhA inhibitors is summarized in this paper.
Export Options
About this article
Cite this article as:
Zhang Yi, Xie Longxiang and Xie Jianping, Progress on the Discovery of Inhibitors of InhA, the FAS II Enoyl-ACP Reductase TB Drug Discovery Targeted on InhA, Letters in Drug Design & Discovery 2016; 13 (6) . https://dx.doi.org/10.2174/1570180812666151016205422
DOI https://dx.doi.org/10.2174/1570180812666151016205422 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Toward Integrase Defective Lentiviral Vectors for Genetic Immunization
Current HIV Research Vitamin D in COPD - A Pleiotropic Micronutrient in a Multisystem Disease
Current Respiratory Medicine Reviews Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade
Letters in Drug Design & Discovery Crosstalk Between The Immune Receptors and Gut Microbiota
Current Protein & Peptide Science Propylene Carbonate as a Solvent in the Eco-Friendly Synthesis of Highly Substituted Imidazoles Through the Radziszewski Reaction
Current Organic Synthesis Structure-based Discovery of Narirutin as a Shikimate kinase Inhibitor with Anti-tubercular Potency
Current Computer-Aided Drug Design Liposome Technology for Drug Delivery Against Mycobacterial Infections
Current Pharmaceutical Design Structure- and Ligand-Based Structure-Activity Relationships for a Series of Inhibitors of Aldolase
Current Computer-Aided Drug Design Slow-Onset Inhibition of 2-trans-Enoyl-ACP (CoA) Reductase from Mycobacterium tuberculosis by an Inorganic Complex
Current Pharmaceutical Design Molecular Imaging of Therapeutic Potential of Reporter Probes
Current Drug Targets Key Targets and Relevant Inhibitors for the Drug Discovery of Tuberculosis
Current Drug Targets Fabrication and Characterization of Oral Dissolving Films for Tuberculosis Drug Delivery
Nanoscience & Nanotechnology-Asia Eco-Friendly and Highly Efficient Synthesis, Including Multigram Synthesis, of Aldehyde Isonicotinoyl Hydrazones Using Sonochemistry
Letters in Organic Chemistry Current Management of Alcoholic Liver Disease
Current Drug Abuse Reviews Synthesis and Antitubercular Screening of Some Novel 4H-1,4- Benzothiazines and their Sulfones Under Environment Benign Solvent Free Conditions as Future Anti-Tubercular Agents
Combinatorial Chemistry & High Throughput Screening Bioinformatics-Coupled Molecular Approaches for Unravelling Potential Antimicrobial Peptides Coding Genes in Brazilian Native and Crop Plant Species
Current Protein & Peptide Science Radical Releasing Anti-tuberculosis Agents and the Treatment of <i>Mycobacterial Tuberculosis</i> Infections - An Overview
Mini-Reviews in Medicinal Chemistry New Aminoacyl-tRNA Synthetase Inhibitors as Antibacterial Agents
Current Drug Targets - Infectious Disorders Evaluation of Small Molecule Tuberculostats for Targeting Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry Meet the Editorial Board:
Current Medicinal Chemistry