It has been over half a century since propranolol, the first beta-blocker, was developed for
medical treatment. Since that time a large number of compounds from this group have been
synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and
mechanism of beta-blockers have been established. The possibilities for their use in treating different
conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol
and nebivolol, the search for new compounds continues, and may include known substances with betablocking
properties which could extend their therapeutic potential.