Background: The widespread application of fluorine in drug design benefits from
distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics
properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which
were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and
evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6
years (2010-2015) are summarized.
Conclusion: The emphasis is to highlight the importance of fluorinated compounds and the changes in
the properties of compounds when introducing fluorine atom.