Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review

Author(s): Bao-Cheng Wang, Li-Jun Wang, Bo Jiang, Shuai-Yu Wang, Ning Wu, Xiang-Qian Li, Da-Yong Shi*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 8 , 2017

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Abstract:

Background: The widespread application of fluorine in drug design benefits from distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6 years (2010-2015) are summarized.

Conclusion: The emphasis is to highlight the importance of fluorinated compounds and the changes in the properties of compounds when introducing fluorine atom.

Keywords: Application of fluorine, anticancer, antimicrobial, anti-inflammatory, antivirus activity, drug design, importance of fluorinated compounds.

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Article Details

VOLUME: 17
ISSUE: 8
Year: 2017
Page: [683 - 692]
Pages: 10
DOI: 10.2174/1389557515666151016124957
Price: $65

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