Treatment-resistant Late-life Depression: Challenges and Perspectives

Author(s): Christian Knochel, Gilberto Alves, Benedikt Friedrichs, Barbara Schneider, Anna Schmidt-Rechau, Sofia Wenzler, Angelina Schneider, David Prvulovic, Andre F. Carvalho, Viola Oertel-Knochel

Journal Name: Current Neuropharmacology

Volume 13 , Issue 5 , 2015

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Graphical Abstract:


The current Review article provides a narrative review about the neurobiological underpinnings and treatment of treatment resistant late-life depression (TRLLD). The manuscript focuses on therapeutic targets of late-life depression, which include pharmacological, psychological, biophysical and exercise treatment approaches. Therefore, we summarize available evidences on that kind of therapies for patients suffering from late-life depression. The search for evidences of therapeutic options of late-life depression were done using searching websites as “pubmed”, and using the searching terms “depression”, “late-life depression”, “treatment”, “biophysical therapy”, “exercise therapy”, “pharmacological therapy” and “psychological therapy”. To the end, we summarize and discuss current data, providing some directions for further research.

Treatment recommendations for elderly depressive patients favour a multimodal approach, containing psychological, pharmacological and secondary biophysical therapeutic options. Particularly, a combination of psychotherapy and antidepressant medication reflects the best therapeutic option. However, mostly accepted and used is the pharmacological treatment although evidence suggests that the drug therapy is not as effective as it is in younger depressive patients. Further studies employing larger samples and longer follow-up periods are necessary and may focus on comparability of study designs and involve novel approaches to establish the validity and reliability of multimodal treatment programs.

Keywords: Antidepressants, electroconvulsive therapy, late-life depression, psychotherapy, review, treatment-resistant.

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Article Details

Year: 2015
Published on: 12 October, 2015
Page: [577 - 591]
Pages: 15
DOI: 10.2174/1570159X1305151013200032
Price: $65

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