siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector

Author(s): Rakesh Kumar Tekade, Rahul G.S. Maheshwari, Piyoosh A. Sharma, Muktika Tekade, Abhay Singh Chauhan

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 31 , 2015

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Abstract:

siRNA technology presents a helpful means of gene silencing in mammalian cells. Advancement in the field includes enhanced attentiveness in the characterization of target and off-target effects employing suitable controls and gene expression microarrays. These will permit expansion in the measurement of single and multiple target combinations and also permit comprehensive efforts to understand mammalian cell processes. Another fact is that the delivery of siRNA requires the creation of a nanoparticulate vector with controlled structural geometry and surface modalities inside the targeted cells. On the other hand, dendrimers represent the class of carrier system where massive control over size, shape and physicochemical properties makes this delivery vector exceptional and favorable in genetic transfection applications. The siRNA therapeutics may be incorporated inside the geometry of the density controlled dendrimers with the option of engineering the structure to the specific needs of the genetic material and its indication. The existing reports on the siRNA carrying and deliverance potential of dendrimers clearly suggest the significance of this novel class of polymeric architecture and certainly elevate the futuristic use of this highly branched vector as genetic material delivery system.

Keywords: Dendrimer, siRNA, nanocarrier, drug delivery, therapy.

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Article Details

VOLUME: 21
ISSUE: 31
Year: 2015
Page: [4614 - 4636]
Pages: 23
DOI: 10.2174/138161282131151013192116
Price: $65

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